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        當前位置: 中華商機網 » 醫藥保養 » 醫藥中間體 »Compound 7P

        Compound 7P

        發布時間  2017-05-16 19:13 國家地區 中國 »江蘇»蘇州市
        發布人 樊繼標 公司  蘇州麥輪生物科技有限公司
        地址  蘇州聚賢路峰匯商務廣場5-1118 網站  蘇州麥輪生物科技有限公司
        郵件  [email protected] 手機  13771770578
        電話  0512-66150687 QQ   172578515點擊這里給我發消息
        用戶級別  普通會員      加入時間  2017年05月16日(距今535天)
        精準匹配 1890208-58-8  Axon regeneration  compound 7p  
        報價 面議
         Chemical Name:
        2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide
        2-[(2-Methoxyphenyl)[4-methylphenyl)sulfonyl]amino]-N-(4-methoxy-3-pyridinyl)acetamide
        CAS: 1890208-58-8
        Reaxys Registry Number: 29568294
        Molecular Formula: C22H23N3O5S
        Linear Structure Formula: C22H23N3O5S
        Molecular Weight: 441.508
        InChI Key: NAXWKPFXCOBXLE-UHFFFAOYSA-N
         
        CAS: 1890208-58-8
         
        Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential, and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways. Here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. In an animal model of optic nerve injury, compound 7p was shown to induce growth of GAP-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo. Further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies. 

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        Compound 7P

        關鍵字1890208-58-8  Axon regeneration  compound 7p  

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